Open AccessEnhanced intraperitoneal delivery of charged, aerosolized curcumin nanoparticles by electrostatic precipitation
Author(s) -
Arianna Castagna,
Alexandra J Zander,
Iaroslaw Sautkin,
Marc Schneider,
Ranjita Shegokar,
Alfred Königsrainer,
Marc A. Reymond
Publication year - 2021
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2020-0373
Subject(s) - plga , intraperitoneal chemotherapy , curcumin , intraperitoneal injection , nanoparticle , precipitation , aerosolization , biophysics , penetration (warfare) , ex vivo , chemistry , materials science , nanotechnology , pharmacology , medicine , anesthesia , in vitro , biochemistry , inhalation , cancer , physics , ovarian cancer , operations research , meteorology , engineering , biology
Aims: To investigate the potential of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-PLGA-NPs), alone and with electrostatic precipitation, for improving tissue uptake during pressurized intraperitoneal aerosol chemotherapy (PIPAC). Methods: Positively and negatively charged CUR-PLGA-NPs were delivered as PIPAC into inverted bovine urinary bladders ex vivo. The experiment was repeated with the additional use of electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (electrostatic PIPAC). Results: Positively charged CUR-PLGA-NPs increased depth of tissue penetration by 81.5% and tissue concentration by 80%. Electrostatic precipitation further improved the uptake of positively charged CUR-PLGA-NPs by 41.8%. Conclusion: The combination of positive charge and electrostatic precipitation have significant potential to improve tissue uptake of nanoparticles during intraperitoneal chemotherapy.