Open AccessDistributions of intravenous injected iodine nanoparticles in orthotopic u87 human glioma xenografts over time and tumor therapy
Author(s) -
Sharif M Ridwan,
Ferris El-Tayyeb,
James F. Hainfeld,
Henry M. Smilowitz
Publication year - 2020
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2020-0178
Subject(s) - glioma , u87 , iodine , medicine , cd31 , cancer research , confocal microscopy , radiation therapy , pathology , staining , chemistry , immunohistochemistry , biology , organic chemistry , microbiology and biotechnology
Aim: To analyze the localization, distribution and effect of iodine nanoparticles (INPs) on radiation therapy (RT) in advanced intracerebral gliomas over time after intravenous injection. Materials & methods: Luciferase/td-tomato expressing U87 human glioma cells were implanted into mice which were injected intravenously with INPs. Mice with gliomas were followed for tumor progression and survival. Immune-stained mouse brain sections were examined and quantified by confocal fluorescence microscopy. Results: INPs injected intravenously 3 days prior to RT, compared with 1 day, showed greater association with CD31-staining structures, accumulated inside tumor cells more, covered more of the tumor cell surface and trended toward increased median survival. Conclusion: INP persistence and redistribution in tumors over time may enable greater RT enhancement and clinically relevant hypo-fractionated-RT and may enhance INP efficacy.