Open AccessCurrent trends in pyrrole and porphyrin-derived nanoscale materials for biomedical applications
Author(s) -
Parinaz Fathi,
Dipanjan Pan
Publication year - 2020
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2020-0125
Subject(s) - porphyrin , photothermal therapy , nanotechnology , photodynamic therapy , photoacoustic imaging in biomedicine , nanoparticle , tetrapyrrole , materials science , pyrrole , drug delivery , chemistry , photochemistry , organic chemistry , optics , physics , enzyme
This article is written to provide an up-to-date review of pyrrole-based biomedical materials. Porphyrins and other tetrapyrrolic molecules possess unique magnetic, optical and other photophysical properties that make them useful for bioimaging and therapy. This review touches briefly on some of the synthetic strategies to obtain porphyrin- and tetrapyrrole-based nanoparticles, as well as the variety of applications in which crosslinked, self-assembled, porphyrin-coated and other nanoparticles are utilized. We explore examples of these nanoparticles' applications in photothermal therapy, drug delivery, photodynamic therapy, stimuli response, fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, computed tomography and positron emission tomography. We anticipate that this review will provide a comprehensive summary of pyrrole-derived nanoparticles and provide a guideline for their further development.