Open AccessInnovative strategies to treat skin wounds with mangiferin: fabrication of transfersomes modified with glycols and mucin
Author(s) -
Mohamad Allaw,
María Pleguezuelos-Villa,
Maria Letizia Manca,
Carla Caddeo,
Matteo Aroffu,
Amparo Nácher,
Octavio Dı́ez-Sales,
Ana Saurı́,
Elisa Ferrer,
Anna Maria Fadda,
Maria Manconi
Publication year - 2020
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2020-0116
Subject(s) - mangiferin , bioadhesive , in vivo , mucin , dermis , wound healing , oxidative stress , pharmacology , chemistry , medicine , biochemistry , drug delivery , surgery , pathology , biology , organic chemistry , microbiology and biotechnology
Aim: The moisturizing properties of glycerol, the penetration enhancing capability of propylene glycol and the bioadhesive properties of mucin were combined to improve the carrier capabilities of transfersomes and the efficacy of mangiferin in the treatment of skin lesions. Materials & methods: Mangiferin was incorporated in transfersomes and glycoltransfersomes, which were also modified with mucin. The physico–chemical features were assessed, along with the efficacy against oxidative stress and skin wounds in vitro and in vivo. Results: Glycoltransfersomes promoted the deposition of mangiferin in epidermis and dermis, protected fibroblasts from oxidative stress and stimulated their proliferation. The wound healing and anti-inflammatory efficacy of glycoltransfersomes were confirmed in vivo. Conclusion: Results confirmed the potential of glycoltransfersomes in preventing/treating of skin lesions.