Open AccessBiomimetic nanovesicle design for cardiac tissue repair
Author(s) -
Sruti Bheri,
Jessica R. Hoffman,
Hyun Ji Park,
Michael Davis
Publication year - 2020
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2020-0097
Subject(s) - microvesicles , homing (biology) , exosome , context (archaeology) , tissue repair , medicine , bioinformatics , biology , microbiology and biotechnology , microrna , biochemistry , ecology , paleontology , gene
Cardiovascular disease is a major cause of mortality and morbidity worldwide. Exosome therapies are promising for cardiac repair. Exosomes transfer cargo between cells, have high uptake by native cells and are ideal natural carriers for proteins and nucleic acids. Despite their proreparative potential, exosome production is dependent on parent cell state with typically low yields and cargo variability. Therefore, there is potential value in engineering exosomes to maximize their benefits by delivering customized, potent cargo for cardiovascular disease. Here, we outline several methods of exosome engineering focusing on three important aspects: optimizing cargo, homing to target tissue and minimizing clearance. Finally, we put these methods in context of the cardiac field and discuss the future potential of vesicle design.