Open AccessFluorescein sodium loaded by polyethyleneimine for fundus fluorescein angiography improves adhesion
Author(s) -
Wenting Cai,
Meixiu Chen,
Jiaqi Fan,
Huizi Jin,
Dong Yu,
Sujing Qiang,
Chen Peng,
Jing Yu
Publication year - 2019
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2019-0008
Subject(s) - sodium fluorescein , fluorescein , fluorescein angiography , fundus fluorescein angiography , fundus (uterus) , adhesion , ophthalmology , fluorescence , medicine , materials science , optics , retinal , physics , composite material
Aim: To improve the retention of fluorescein sodium (FS) as a kind of clinical contrast agent for fundus fluorescein angiography (FFA). Materials & methods: Polyethyleneimine (PEI) was designed to synthesize PEI–NHAc–FS nanoparticles (NPs), and the formed NPs were characterized by both physicochemical properties and their effects on FFA. Results: Compared with free FS, PEI–NHAc–FS NPs showed similar optical performance, and could obviously reduce cellular adsorption and uptake both in vitro and in vivo, which could promote the metabolism of NPs in ocular blood vessels. Conclusion: PEI–NHAc–FS NPs represent a smart nanosize fluorescence contrast agent, which hold promising potential for clinical FFA diagnosis, therapy and research work.