Open AccessImproved brain delivery of pueraria flavones via intranasal administration of borneol-modified solid lipid nanoparticles
Author(s) -
Liping Wang,
Xiao Guang Zhao,
Junfeng Du,
Mei Liu,
Feng Jiao,
Kaili Hu
Publication year - 2019
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2018-0417
Subject(s) - solid lipid nanoparticle , nasal administration , borneol , flavones , puerarin , pharmacology , in vivo , chemistry , drug delivery , chromatography , medicine , drug , organic chemistry , biology , alternative medicine , microbiology and biotechnology , traditional chinese medicine , pathology
Aim: To improve the drug delivery to the brain with borneol (Bo)-modified solid lipid nanoparticles (SLNs) of pueraria flavones (PTF) via intranasal administration. Materials & methods: PTF-loaded SLNs were modified with Bo by physical and chemical methods to synthesize PTF-Bo-SA-SLNs and PTF-Bo-SLNs. The prepared SLNs were characterized and their brain delivery effects were evaluated in vitro and in vivo. Results: There was a more pronounced accumulation of PTF-Bo-SA-SLNs in Caco-2 cells. Following intranasal administration, more coumarin-6 was found in the rat brain carried by Bo-SA-SLNs. Brain area under the curve and C max of PTF-Bo-SA-SLN were 7.31- and 7.29-times higher than those of PTF-SLN, respectively. Conclusion: PTF-Bo-SA-SLNs are a promising therapeutic carrier for brain disease after intranasal administration.