Open AccessBiodistribution and toxicity of orally administered poly (lactic-co-glycolic) acid nanoparticles to F344 rats for 21 days
Author(s) -
Sara Navarro,
Timothy W. Morgan,
Carlos E. Astete,
Rhett W. Stout,
Diana Coulon,
Peter Mottram,
Cristina M. Sabliov
Publication year - 2016
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2016-0022
Subject(s) - plga , biodistribution , toxicity , alkaline phosphatase , glycolic acid , pharmacology , chemistry , alanine transaminase , aspartate transaminase , transaminase , small intestine , lactic acid , biochemistry , medicine , enzyme , biology , in vitro , organic chemistry , bacteria , genetics
Aim: Quantify the biodistribution and assess the toxicity of PLGA (poly-lactic-co-glycolic acid) and surface-modified PLGA chitosan (PLGA/Chi) nanoparticles (NPs) orally administered for 7, 14 and 21 days to F344 rats. Materials & methods: Fluorescent NPs were tracked in F344 rat tissues, and toxicity was evaluated by alkaline phosphatase and alanine transaminase levels, and by histologic examination of tissue samples. Results: Biodistribution of PLGA and PLGA/Chi were similar, with highest amounts found in the intestine and liver. Alkaline phosphatase increased significantly in treated rats. Mild histological differences were detected in the intestine and liver. Conclusion: PLGA and PLGA/Chi NPs behaved similarly presenting minimal toxicity in the liver and intestine, but not in kidney, lung and brain.