Targeting Mitochondrial Metal Dyshomeostasis for the Treatment of Neurodegeneration | Zendy

Jeffrey R. Liddell | Zendy

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Targeting Mitochondrial Metal Dyshomeostasis for the Treatment of Neurodegeneration

Author(s) -

Jeffrey R. Liddell

Publication year - 2015

Publication title -

neurodegenerative disease management

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.674

H-Index - 23

eISSN - 1758-2032

pISSN - 1758-2024

DOI - 10.2217/nmt.15.19

Subject(s) - neurodegeneration , amyotrophic lateral sclerosis , ataxia , neuroscience , mitochondrion , disease , homeostasis , medicine , iron homeostasis , parkinson's disease , bioinformatics , pathology , biology , microbiology and biotechnology , metabolism

Mitochondrial impairment and metal dyshomeostasis are suggested to be associated with many neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and Friedreich's ataxia. Treatments aimed at restoring metal homeostasis are highly effective in models of these diseases, and clinical trials hold promise. However, in general, the effect of these treatments on mitochondrial metal homeostasis is unclear, and the contribution of mitochondrial metal dyshomeostasis to disease pathogenesis requires further investigation. This review describes the role of metals in mitochondria in health, how mitochondrial metals are disrupted in neurodegenerative diseases, and potential therapeutics aimed at restoring mitochondrial metal homeostasis and function.

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