Hippocampal Subfields and Decline in Activities of Daily Living in Alzheimer’s Disease and Dementia With Lewy Bodies | Zendy

Miguel Germán Borda | Zendy; Alberto JaramilloJimenez | Zendy; Diego Tovar | Zendy; Daniel Ferreira | Zendy; Elkin García-Cifuentes | Zendy; Audun Osland VikMo | Zendy; Vera Aarsland | Zendy; Dag Aarsland | Zendy; Ketil Oppedal | Zendy

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Hippocampal Subfields and Decline in Activities of Daily Living in Alzheimer’s Disease and Dementia With Lewy Bodies

Author(s) -

Miguel Germán Borda,

Alberto JaramilloJimenez,

Diego Tovar,

Daniel Ferreira,

Elkin García-Cifuentes,

Audun Osland VikMo,

Vera Aarsland,

Dag Aarsland,

Ketil Oppedal

Publication year - 2020

Publication title -

neurodegenerative disease management

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.674

H-Index - 23

eISSN - 1758-2032

pISSN - 1758-2024

DOI - 10.2217/nmt-2020-0039

Subject(s) - dementia with lewy bodies , dementia , hippocampal formation , clinical dementia rating , atrophy , cognitive decline , neuroscience , psychology , alzheimer's disease , disease , cognition , medicine , psychiatry , audiology

Background: Hippocampal atrophy is presented in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Cognition, dual-tasks, muscular function, goal-related behaviors and neuropsychiatric symptoms are linked to hippocampal volumes and may lead to functional decline in activities of daily living. We examined the association between baseline hippocampal subfield volumes (HSv) in mild AD and DLB, and functional decline. Materials & methods: 12 HSv were computed from structural magnetic resonance images using Freesurfer 6.0 segmentation. Functional decline was assessed using the rapid disability rating scale score. Linear regressions were conducted. Results: In AD, HSv were smaller bilaterally. However, HSv were not associated with functional decline. Conclusion: Functional decline does not depend on HSv in mild AD and DLB.

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