Open AccessEffectiveness of durvalumab consolidation in stage III non-small-cell lung cancer: focus on treatment selection and prognostic factors
Author(s) -
Maja Guberina,
Nika Guberina,
Christoph Pöttgen,
Thomas Gauler,
Cedric Richlitzki,
Martin Metzenmacher,
Marcel Wiesweg,
Till Plönes,
Michael Forsting,
Axel Wetter,
Ken Herrmann,
Hubertus Hautzel,
Kaid Darwiche,
Dirk Theegarten,
Clemens Aigner,
Martin Schüler,
Martin Stuschke,
W. Eberhardt
Publication year - 2022
Publication title -
immunotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.127
H-Index - 48
eISSN - 1750-7448
pISSN - 1750-743X
DOI - 10.2217/imt-2021-0341
Subject(s) - durvalumab , medicine , oncology , hazard ratio , lung cancer , propensity score matching , stage (stratigraphy) , performance status , chemotherapy , confounding , cancer , confidence interval , immunotherapy , paleontology , nivolumab , biology
The pivotal PACIFIC trial defined durvalumab consolidation as the new standard of care in patients with stage III non-small-cell lung cancer treated with definitive radiochemotherapy. The authors characterized the durvalumab effect after induction chemotherapy according to the ESPATUE trial and definitive radiochemotherapy. All consecutive patients with stage III non-small-cell lung cancer receiving definitive radiochemotherapy between January 2017 and February 2020 were included. Primary end points were progression-free survival and overall survival. Altogether, 160 patients (75 PD-L1-positive, 62 PD-L1-negative, 23 unknown) received definitive radiochemotherapy, 146 (91%) of whom received prior induction chemotherapy. Durvalumab consolidation showed high effectiveness overall and in the good-risk group according to the PACIFIC trial (log-rank test: p < 0.005). Hazard ratios for progression-free survival and overall survival were at the lower limits of those in the PACIFIC trial. These results were robust to adjustment for potential confounders by propensity score weighting. Eastern Cooperative Oncology Group (ECOG) performance status was the most important pretreatment prognostic factor.