Open AccessPlasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory
Author(s) -
Yang Liu,
Pakawat Chongsathidkiet,
Bridget M. Crawford,
Ren Odion,
Cosette Dechant,
Hanna Kemeny,
Xiuyu Cui,
Paolo F. Maccarini,
Christopher D. Lascola,
Peter E. Fecci,
Tuan VoDinh
Publication year - 2019
Publication title -
immunotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.127
H-Index - 48
eISSN - 1750-7448
pISSN - 1750-743X
DOI - 10.2217/imt-2019-0023
Subject(s) - photothermal therapy , immunotherapy , medicine , radiation therapy , cancer research , glioma , immune system , brain tumor , immunology , pathology , materials science , nanotechnology
Brain tumors present unique therapeutic challenges and they include glioblastoma (GBM) and metastases from cancers of other organs. Current treatment options are limited and include surgical resection, radiation therapy, laser interstitial thermal therapy and chemotherapy. Although much research has been done on the development of immune-based treatment platforms, only limited success has been demonstrated. Herein, we demonstrate a novel treatment of GBM through the use of plasmonic gold nanostars (GNS) as photothermal inducers for synergistic i m muno pho tothermal n anotherap y (SYMPHONY), which combines treatments using gold nanostar and laser-induced photothermal therapy with checkpoint blockade immunotherapy. In the treatment of a murine flank tumor model with the CT-2A glioma cell line, SYMPHONY demonstrated the capability of producing long-term survivors that rejects rechallenge with cancer cells, heralding the successful emergence of immunologic memory. This study is the first to investigate the use of this novel therapy for the treatment of GBM in a murine model.