Open AccessConcordant acute myeloblastic leukemia in identical twins treated with allogeneic transplantation from a younger HLA-identical sibling following a single apheresis procedure
Author(s) -
Yajaira Valentine Jiménez-Antolinez,
Elías Eugenio GonzálezLópez,
Ileana Yazmín Velasco Ruiz,
Marcela Cantu-Moreno,
David GómezAlmaguer,
Óscar González-Llano
Publication year - 2021
Publication title -
international journal of hematologic oncology
Language(s) - English
Resource type - Journals
eISSN - 2045-1407
pISSN - 2045-1393
DOI - 10.2217/ijh-2020-0017
Subject(s) - medicine , acute myeloblastic leukemia , sibling , minimal residual disease , human leukocyte antigen , immunology , myeloid leukemia , hematopoietic stem cell transplantation , identical twins , apheresis , transplantation , myeloid , leukemia , pediatrics , antigen , platelet , psychology , developmental psychology
A concordant leukemia is that which occurs in a pair of monozygotic twins; a similar genetic background suggests an in utero monoclonal origin. We present the case of a pair of monozygotic infants with concordant acute myeloid leukemia who underwent a peripheral blood hematopoietic stem-cell transplant (HSCT) from a single, younger human leukocyte antigen-identical sibling donor, using a fractioned graft collected during only one apheresis procedure. Twin A relapsed at +456 and received a second haploidentical HSCT from his father, twin B has been in complete remission since the first HSCT. Both children are in complete remission and with negative minimal residual disease at +900 (after second transplant) and +1488, respectively.