Open AccessRadioimmunotherapy-based conditioning regimen prior to autologous stem cell transplantation in non-Hodgkin lymphoma
Author(s) -
Mahsa Eskian,
MirHojjat Khorasanizadeh,
Alessandro Isidori,
Nima Rezaei
Publication year - 2018
Publication title -
international journal of hematologic oncology
Language(s) - English
Resource type - Journals
eISSN - 2045-1407
pISSN - 2045-1393
DOI - 10.2217/ijh-2017-0025
Subject(s) - radioimmunotherapy , medicine , autologous stem cell transplantation , lymphoma , transplantation , oncology , non hodgkin's lymphoma , regimen , stem cell , conditioning regimen , monoclonal antibody , hematopoietic stem cell transplantation , immunology , antibody , biology , genetics
Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy and the sixth cause of death from cancer in the USA. Autologous stem cell transplantation (ASCT) is a potentially curative therapeutic option for many NHL patients. Choosing the most effective conditioning regimen prior to ASCT can lead to longer survival in these patients, and, as in many cases of high risk NHL, the only potentially curative option is stem cell transplantation. Radioimmunotherapy (RIT) is based on using radiolabeled monoclonal antibodies against tumoral antigens. Since lymphoma cells are sensitive to radiation, RIT has become a potential approach in treating NHL. In this review, we have discussed the efficacy and safety of RIT as an alternative conditioning regimen prior to ASCT.