Open AccessNon-SARS, non-MERS human coronavirus infections and risk of Kawasaki disease: a meta-analysis
Author(s) -
Pratap Kumar Patra,
Rashmi Ranjan Das,
Aaqib Zaffar Banday,
Mini P. Singh,
Kapil Goyal,
Ankur Kumar Jindal,
Surjit Singh
Publication year - 2022
Publication title -
future virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.462
H-Index - 34
eISSN - 1746-0808
pISSN - 1746-0794
DOI - 10.2217/fvl-2021-0176
Subject(s) - kawasaki disease , medicine , observational study , coronavirus , covid-19 , disease , meta analysis , virology , infectious disease (medical specialty) , outbreak , artery
Aim: To study the association between non-SARS, non-MERS human coronavirus (HCoV) infections and Kawasaki disease (KD). Methods: Meta-analysis of observational studies published until 1 May 2021. Results: Out of 571 papers retrieved through database search, 10 provided data of 17,732 children. Age ranged from 2 months-14.9 years with 66% being male and 71% being complete KD. Compared with controls, there was an increased risk of developing KD in those detected to have HCoV infection (OR: 2.3 [95% CI: 1.06-4.99]; p = 0.03). The GRADE evidence for all outcomes was of 'low-certainty'. Conclusion: A 'low certainty' of evidence suggests an increased risk of KD in children infected with HCoV. We need multi-center, prospective studies to support or refute this finding. PROSPERO protocol registration : CRD42021251582.