Non-SARS, Non-MERS Human Coronavirus Infections and Risk of Kawasaki Disease: A meta-analysis | Zendy

Pratap Kumar Patra | Zendy; Rashmi Ranjan Das | Zendy; Aaqib Zaffar Banday | Zendy; Mini P. Singh | Zendy; Kapil Goyal | Zendy; Ankur Kumar Jindal | Zendy; Surjit Singh | Zendy

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Non-SARS, Non-MERS Human Coronavirus Infections and Risk of Kawasaki Disease: A meta-analysis

Author(s) -

Pratap Kumar Patra,

Rashmi Ranjan Das,

Aaqib Zaffar Banday,

Mini P. Singh,

Kapil Goyal,

Ankur Kumar Jindal,

Surjit Singh

Publication year - 2021

Publication title -

future virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.462

H-Index - 34

eISSN - 1746-0808

pISSN - 1746-0794

DOI - 10.2217/fvl-2021-0176

Subject(s) - kawasaki disease , medicine , observational study , coronavirus , covid-19 , disease , meta analysis , virology , infectious disease (medical specialty) , outbreak , artery

Aim: To study the association between non-SARS, non-MERS human coronavirus (HCoV) infections and Kawasaki disease (KD). Methods: Meta-analysis of observational studies published until 1 May 2021. Results: Out of 571 papers retrieved through database search, 10 provided data of 17,732 children. Age ranged from 2 months-14.9 years with 66% being male and 71% being complete KD. Compared with controls, there was an increased risk of developing KD in those detected to have HCoV infection (OR: 2.3 [95% CI: 1.06-4.99]; p = 0.03). The GRADE evidence for all outcomes was of 'low-certainty'. Conclusion: A 'low certainty' of evidence suggests an increased risk of KD in children infected with HCoV. We need multi-center, prospective studies to support or refute this finding. PROSPERO protocol registration : CRD42021251582.

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