Detection and Predictors of anti-SARS-CoV-2 Antibody Levels in COVID-19 Patients at 8 Months After Symptom Onset | Zendy

Jing Guo | Zendy; Li Li | Zendy; Qian Wu | Zendy; Hongwei Li | Zendy; Yajie Li | Zendy; Xinwei Hou | Zendy; Fangfei Yang | Zendy; Zhonghua Qin | Zendy

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Detection and Predictors of anti-SARS-CoV-2 Antibody Levels in COVID-19 Patients at 8 Months After Symptom Onset

Author(s) -

Jing Guo,

Li Li,

Qian Wu,

Hongwei Li,

Yajie Li,

Xinwei Hou,

Fangfei Yang,

Zhonghua Qin

Publication year - 2021

Publication title -

future virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.462

H-Index - 34

eISSN - 1746-0808

pISSN - 1746-0794

DOI - 10.2217/fvl-2021-0141

Subject(s) - medicine , antibody , covid-19 , immunology , viral shedding , severity of illness , immunity , disease , immune system , virology , infectious disease (medical specialty) , outbreak

Aim: To determine SARS-CoV-2 specific IgM and IgG levels of patients with COVID-19 at 8 months after symptom onset and to explore the predictors of antibody levels. Materials & methods: The magnetic chemiluminescence method was used to measure the antibody levels. Clinical data were collected and analyzed retrospectively. Results: A total of 54 patients were enrolled in this study, of whom 59.3% were IgM positive and 96.4% were IgG positive. The multiple linear regression analysis revealed that the duration of RNA shedding, C-reactive protein level and disease severity were independent predictors of IgG levels. Conclusion: COVID-19 patients retained long-term viral-specific protective immunity. Disease severity, C-reactive protein level and duration of RNA shedding were related to antibody levels 8 months after symptom onset.

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