Open AccessDetection and predictors of anti-SARS-CoV-2 antibody levels in COVID-19 patients at 8 months after symptom onset
Author(s) -
Jing Guo,
Li Li,
Qian Wu,
Hongwei Li,
Yajie Li,
Xiaonan Hou,
Fan Yang,
Zhonghua Qin
Publication year - 2021
Publication title -
future virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.462
H-Index - 34
eISSN - 1746-0808
pISSN - 1746-0794
DOI - 10.2217/fvl-2021-0141
Subject(s) - medicine , antibody , covid-19 , immunology , viral shedding , severity of illness , immunity , disease , immune system , virology , infectious disease (medical specialty) , outbreak
Aim: To determine SARS-CoV-2 specific IgM and IgG levels of patients with COVID-19 at 8 months after symptom onset and to explore the predictors of antibody levels. Materials & methods: The magnetic chemiluminescence method was used to measure the antibody levels. Clinical data were collected and analyzed retrospectively. Results: A total of 54 patients were enrolled in this study, of whom 59.3% were IgM positive and 96.4% were IgG positive. The multiple linear regression analysis revealed that the duration of RNA shedding, C-reactive protein level and disease severity were independent predictors of IgG levels. Conclusion: COVID-19 patients retained long-term viral-specific protective immunity. Disease severity, C-reactive protein level and duration of RNA shedding were related to antibody levels 8 months after symptom onset.