Open AccessThoughts On Detecting Tissue Distribution of Potential COVID-19 Receptors
Author(s) -
Hongtao Tang,
Xiaosheng Lu,
Shuyan Qie,
Jianing Xi
Publication year - 2020
Publication title -
future virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.462
H-Index - 34
eISSN - 1746-0808
pISSN - 1746-0794
DOI - 10.2217/fvl-2020-0136
Subject(s) - covid-19 , virology , receptor , distribution (mathematics) , tissue distribution , biology , computational biology , medicine , pathology , physiology , mathematics , genetics , outbreak , infectious disease (medical specialty) , mathematical analysis , disease
Aim: As a novel coronavirus, coronavirus disease 2019 (COVID-19) has caused a global epidemic. Many clinical data show that COVID-19 can not only cause viral pneumonia but also damage a variety of target organs. Materials & methods: We searched some open online datasets, such as Gene ORGANizer, the Human Protein Atlas and Pubmed, to explore the tissue distribution of potential COVID-19 receptors (ACE2, CD209, CLEC4M and BSG) in the human body. Results: The above potential COVID-19 receptors were highly expressed in the lungs, intestine, kidney, liver, heart, testis, placenta, hematopoietic tissue and nerve tissue. Conclusion: It is speculated that they may be potentially high-risk organs susceptible to COVID-19 infection. It is expectant to provide some help for further research in the future.
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