Open AccessAnalysis of full-length hepatitis B virus genome from chronic hepatitis B-patients with higher alanine aminotransferase elevation
Author(s) -
Hiroshi Takahashi,
Tatsuo Kanda,
Naoki Matsumoto,
Toshikatsu Shibata,
Kazushige Nirei,
Akinori Tamura,
Satoshi Matsuoka,
Kensuke Kuroda,
Mitsuhiko Moriyama
Publication year - 2020
Publication title -
future virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.462
H-Index - 34
eISSN - 1746-0808
pISSN - 1746-0794
DOI - 10.2217/fvl-2020-0104
Subject(s) - hepatitis b virus , alanine aminotransferase , virology , alanine , medicine , hepatitis b , nucleoside , virus , biology , amino acid , genetics
Background & aim: Higher elevation of alanine aminotransferase (ALT) occasionally leads to severe outcomes in hepatitis B virus (HBV)-infected patients. Our aim is to investigate the HBV sequence mutations associated with higher ALT elevation. Materials & methods: We analyzed full-length HBV sequences from patients with or without higher ALT elevation. Results: Nucleotide mutations in precore and core regions, which are associated with severe hepatitis B, were found in two HBV-infected patients with higher ALT elevation. Amino acid mutations within the pre-S1, pre-S2 and S regions were also found in a patient with HBV virologic breakthrough during the use of nucleoside analogs. Conclusion: It may be useful for HBV-infected patients with higher ALT elevation to analyze full-length HBV genome.