Cortical Dysplasia: A Possible Substrate for Brain Tumors | Zendy

Shiyong Liu | Zendy; Chunqing Zhang | Zendy; Haifeng Shu | Zendy; Didier Wion | Zendy; Hui Yang | Zendy

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Cortical Dysplasia: A Possible Substrate for Brain Tumors

Author(s) -

Shiyong Liu,

Chunqing Zhang,

Haifeng Shu,

Didier Wion,

Hui Yang

Publication year - 2012

Publication title -

future oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.857

H-Index - 72

eISSN - 1744-8301

pISSN - 1479-6694

DOI - 10.2217/fon.12.6

Subject(s) - neural stem cell , stem cell , progenitor cell , carcinogenesis , pathology , cortical dysplasia , medicine , cancer stem cell , cancer research , dysplasia , adult stem cell , progenitor , brain tumor , embryonic stem cell , biology , neuroscience , microbiology and biotechnology , cancer , genetics , gene , epilepsy

The similarities between brain tumor stem cells and neural stem cells suggest a possible stem cell origin of tumorigenesis. Recently, cells with features of stem cells have been observed in lesions of adult and pediatric cortical dysplasia (CD). Given the evidence for a close relationship between CD and certain brain tumors, together with the finding that CD neural stem cells/progenitors are abnormally developed, we propose that CD is a possible substrate for brain tumors. The neural stem cells/progenitors in CD have accumulating abnormalities, and these abnormal stem/progenitor cells may be the initiating, transformed cells of brain tumors, when subsequently exposed to a carcinogen.

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