Open AccessCortical dysplasia: a possible substrate for brain tumors
Author(s) -
Shiyong Liu,
Chunqing Zhang,
Hai-Feng Shu,
Didier Wion,
Hui Yang
Publication year - 2012
Publication title -
future oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 72
eISSN - 1744-8301
pISSN - 1479-6694
DOI - 10.2217/fon.12.6
Subject(s) - neural stem cell , stem cell , progenitor cell , carcinogenesis , pathology , cortical dysplasia , medicine , cancer stem cell , cancer research , dysplasia , adult stem cell , progenitor , brain tumor , embryonic stem cell , biology , neuroscience , microbiology and biotechnology , cancer , genetics , gene , epilepsy
The similarities between brain tumor stem cells and neural stem cells suggest a possible stem cell origin of tumorigenesis. Recently, cells with features of stem cells have been observed in lesions of adult and pediatric cortical dysplasia (CD). Given the evidence for a close relationship between CD and certain brain tumors, together with the finding that CD neural stem cells/progenitors are abnormally developed, we propose that CD is a possible substrate for brain tumors. The neural stem cells/progenitors in CD have accumulating abnormalities, and these abnormal stem/progenitor cells may be the initiating, transformed cells of brain tumors, when subsequently exposed to a carcinogen.