Open AccessPrognostic value of GPC5 polymorphism rs2352028 and clinical characteristics in Chinese lung cancer patients
Author(s) -
Fan Wang,
Yutao Li,
Zhengxing Li,
Zixiu Zou,
Yongming Lu,
Chang Xu,
ZongXu Zhao,
HuaiZhou Wang,
Yi Wang,
Shicheng Guo,
Li Jin,
Jiucun Wang,
Qiang Li,
Gengxi Jiang,
Fan Xia,
Bo Shen,
Junjie Wu
Publication year - 2022
Publication title -
future oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 72
eISSN - 1744-8301
pISSN - 1479-6694
DOI - 10.2217/fon-2022-0319
Subject(s) - lung cancer , medicine , genotype , oncology , proportional hazards model , gastroenterology , gene , genetics , biology
Background: GPC5 rs2352028 is associated with the risk of lung cancer, but its relationship with lung cancer prognosis is unclear. Materials & methods: The authors collected blood samples from 888 patients with lung cancer and used a Cox proportional hazards model to analyze the association between prognosis and GPC5 polymorphism rs2352028. Results: GPC5 rs2352028 C > T was associated with a better prognosis. Patients with CT genotype had longer overall survival than those with CC genotype. Additionally, older and early-stage patients with CT + TT genotype had a lower risk of death than those with CC genotype. Conclusion: GPC5 rs2352028 C > T may play a protective role in patients with lung cancer and GPC5 rs2352028 may be a potential genetic marker for lung cancer prognosis.