Open AccessGBAP1 polymorphisms (rs140081212, rs1057941 and rs2990220) contribute to reduced risk of gastric cancer
Author(s) -
Xianglong Duan,
Liang Shan,
Shuai Shi,
Boyu Xu,
Xin Chen,
Jinqin Di,
Bopeng Chen,
Xiaoqing Li,
Sida Liu,
Yuhe Wang,
Wei Yang
Publication year - 2022
Publication title -
future oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 72
eISSN - 1744-8301
pISSN - 1479-6694
DOI - 10.2217/fon-2021-0973
Subject(s) - medicine , odds ratio , logistic regression , gastric adenocarcinoma , genotype , oncology , cancer , gastroenterology , adenocarcinoma , genetics , gene , biology
Aim: This study was designed to evaluate the contribution of GBAP1 variants to gastric cancer (GC) risk in a Chinese Han population. Methods: The genotypes of GBAP1 polymorphisms were detected using the Agena MassARRAY platform. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% CIs. Results: GBAP1 rs140081212 (OR = 0.51, p = 4.50 × 10 -07 ), rs1057941 (OR = 0.48, p = 1.19 × 10 -08 ) and rs2990220 (OR = 0.46, p = 7.34 × 10 -09 ) contribute to reduced GC risk, especially gastric adenocarcinoma. Interestingly, the contribution of GBAP1 variants to GC susceptibility was associated with age, sex, BMI, smoking and drinking. Conclusion: This research suggested that GBAP1 polymorphisms might provide a protective effect against GC occurrence in a Chinese Han population.
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