Intraperitoneal Infusion of Recombinant Human Endostatin Improves Prognosis in Gastric Cancer Ascites | Zendy

Zhouwei Zhan | Zendy; Xiaojie Wang | Zendy; Jiami Yu | Zendy; Jingxian Zheng | Zendy; Yi Zeng | Zendy; Mingyao Sun | Zendy; Peng Li | Zendy; Zengqing Guo | Zendy; Bijuan Chen | Zendy

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Intraperitoneal Infusion of Recombinant Human Endostatin Improves Prognosis in Gastric Cancer Ascites

Author(s) -

Zhouwei Zhan,

Xiaojie Wang,

Jiami Yu,

Jingxian Zheng,

Yi Zeng,

Mingyao Sun,

Peng Li,

Zengqing Guo,

Bijuan Chen

Publication year - 2022

Publication title -

future oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.857

H-Index - 72

eISSN - 1744-8301

pISSN - 1479-6694

DOI - 10.2217/fon-2021-0896

Subject(s) - medicine , ascites , cisplatin , adverse effect , gastroenterology , cancer , recombinant dna , endostatin , oncology , chemotherapy , angiogenesis , biochemistry , chemistry , gene

Objective: To investigate the efficacy and safety of intraperitoneal administration of recombinant human endostatin in gastric cancer with malignant ascites. Methods: Clinical data of 90 patients (37 in an Endostar ® combined with cisplatin group and 53 in a cisplatin group) were retrospectively analyzed. The primary end point was overall survival, and the secondary end points were objective response rate (ORR), disease control rate (DCR) and so on. Results: Median overall survival was longer in the combination group (9.7 vs 8.1 months; p = 0.01). ORR and DCR were higher in the combination group (ORR: 75.7% vs 54.7%; p = 0.04; DCR: 94.6% vs 75.5%; p = 0.02). There were no significant differences in adverse effects between the two groups. Conclusion: Intraperitoneal administration of recombinant human endostatin improved efficacy and survival for gastric cancer with ascites.

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