Open AccessReal-world outcomes in locally advanced or metastatic urothelial carcinoma following platinum and PD-1/L1 inhibitor therapy
Author(s) -
Zsolt Hepp,
Sonali Shah,
Shang-Ying Liang,
Katherine Tan,
Shreya Balakrishna
Publication year - 2021
Publication title -
future oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 72
eISSN - 1744-8301
pISSN - 1479-6694
DOI - 10.2217/fon-2021-0573
Subject(s) - medicine , taxane , oncology , metastatic urothelial carcinoma , urothelial carcinoma , progression free survival , population , overall survival , cancer , bladder cancer , environmental health , breast cancer
Aim: To investigate real-world overall survival (rwOS) and real-world progression-free survival (rwPFS) in locally advanced/metastatic urothelial carcinoma postplatinum and postprogrammed death receptor-1/death ligand 1 inhibitors. Patients & methods: Adult patients diagnosed with locally advanced/metastatic urothelial carcinoma from 1 January 2011 to 31 December 2018 and treated with taxane monotherapy or any therapy postplatinum and post-PD-1/L1 inhibitors were included from a nationwide electronic health record-derived oncology database. Results: Median rwOS among 72 patients treated with taxane monotherapy was 7.6 months (95% CI: 5.2–14.4) and rwPFS was 2.9 months (95% CI: 2.4–4.0). Among 208 patients treated with any therapy, median rwOS was 8.9 months (95% CI: 7.3–10.6) and rwPFS was 3.6 months (95% CI: 2.7–4.7). Conclusion: Short duration of rwOS and rwPFS were observed, highlighting the need for effective and safe treatments in this patient population.