Open AccessReal-world treatment patterns and effectiveness outcomes in patients with early-stage triple-negative breast cancer
Author(s) -
Amin Haiderali,
Whitney Rhodes,
Santosh Gautam,
Min Huang,
Jan Sieluk,
Karen E Skinner,
Lee S. Schwartzberg
Publication year - 2021
Publication title -
future oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 72
eISSN - 1744-8301
pISSN - 1479-6694
DOI - 10.2217/fon-2021-0530
Subject(s) - medicine , triple negative breast cancer , breast cancer , oncology , stage (stratigraphy) , cancer , proportional hazards model , neoadjuvant therapy , estrogen receptor , progesterone receptor , retrospective cohort study , paleontology , biology
Background: This retrospective, observational study examined real-world treatment patterns and effectiveness outcomes in 450 patients with stage II–IIIB early-stage triple-negative breast cancer treated in the community oncology setting. Methods: Kaplan–Meier methods were used to evaluate event-free survival (EFS), time to recurrence and overall survival (OS). Cox regression models were used to evaluate predictors of EFS and OS by pathological complete response (pCR) status. Results: Among patients receiving neoadjuvant systemic therapy only, pCR was a predictor of EFS and OS. Conclusion: These results highlight the unmet need for therapies that improve outcomes for patients with early-stage triple-negative breast cancer including increasing rates of pCR among patients receiving neoadjuvant therapy.