Optimal Examined Lymph Node Count in Node-Negative Colon Cancer Should be Determined | Zendy

Huolun Feng | Zendy; Zejian Lyu | Zendy; Weijun Liang | Zendy; Guanfu Cai | Zendy; Zhenru Deng | Zendy; Meiyu Jiang | Zendy; Deqing Wu | Zendy; Yong Li | Zendy

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Optimal Examined Lymph Node Count in Node-Negative Colon Cancer Should be Determined

Author(s) -

Huolun Feng,

Zejian Lyu,

Weijun Liang,

Guanfu Cai,

Zhenru Deng,

Meiyu Jiang,

Deqing Wu,

Yong Li

Publication year - 2021

Publication title -

future oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.857

H-Index - 72

eISSN - 1744-8301

pISSN - 1479-6694

DOI - 10.2217/fon-2021-0113

Subject(s) - medicine , proportional hazards model , colorectal cancer , lymph node , cutoff , confounding , hazard ratio , oncology , covariate , survival analysis , statistics , cancer , mathematics , confidence interval , physics , quantum mechanics

Background: We aimed to investigate the association between optimal examined lymph node (ELNs) and overall survival to determine the optimal cutoff point. Methods: Cox models and locally weighted scatterplot smoothing were used to fit hazard ratios and explore an optimal cutoff point based on the Chow test. Results: Overall survival increased significantly with the corresponding increase in the number of ELNs after adjusting for covariates. In Chow's test, the optimal cutoff point for node-negative colon cancer was 15, which was validated in both cohorts after controlling for confounders (Surveillance, Epidemiology, and End Results database: hazard ratio: 0.701, p < 0.001; single-center: HR: 0.563; p = 0.031). Conclusions: We conservatively suggest that the optimal number of ELNs for prognostic stratification is 15 in node-negative colon cancer.

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