Open AccessParp Inhibitor Treatment of Advanced Breast Cancer Beyond the BRCA -Mutated Type: A Meta-Analysis
Author(s) -
Feifei Yan,
Qi Jiang,
Mengye He,
Peng Shen
Publication year - 2021
Publication title -
future oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 72
eISSN - 1744-8301
pISSN - 1479-6694
DOI - 10.2217/fon-2020-1175
Subject(s) - medicine , oncology , parp inhibitor , breast cancer , meta analysis , chemotherapy , regimen , randomized controlled trial , brca mutation , clinical trial , cancer , poly adp ribose polymerase , biochemistry , chemistry , polymerase , gene
Background: We conducted this meta-analysis to compare the efficacy and safety of PARP inhibitors with or without chemotherapy versus chemotherapy alone for advanced breast cancer. Methods: A meta-analysis and trial sequential analysis were performed using RevMan 5.2 analysis software. Results: Six eligible randomized clinical trials involving 2080 patients were included. Regimens containing PARP inhibitors were significantly associated with higher objective response rate, longer progression-free survival and overall survival. The PARP inhibitor regimen group had a significantly higher rate of grade ≥3 thrombocytopenia than the chemotherapy-only group. Conclusion: Regimens containing PARP inhibitors are effective and safe for BRCA-mutated advanced breast cancer patients. The efficacy appears to be only marginal in patients with BRCA status unselected.
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