Open AccessReal-world outcomes associated with liposomal irinotecan dose reductions in metastatic pancreatic ductal adenocarcinoma
Author(s) -
George P. Kim,
Andy Surinach,
Frank A. Corvino,
Paul Cockrum,
Bruce Belanger,
Laith Abushahin
Publication year - 2021
Publication title -
future oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 72
eISSN - 1744-8301
pISSN - 1479-6694
DOI - 10.2217/fon-2020-0902
Subject(s) - medicine , pancreatic ductal adenocarcinoma , discontinuation , irinotecan , pancreatic cancer , oncology , adenocarcinoma , retrospective cohort study , cancer , colorectal cancer
Aim: This study sought to understand the association between liposomal irinotecan dose reductions (DRs) and clinical outcomes among patients with metastatic pancreatic ductal adenocarcinoma. Materials & methods: A retrospective study of adult patients with metastatic pancreatic ductal adenocarcinoma treated with liposomal irinotecan in the Flatiron Health database was conducted to assess treatment and clinical outcomes. Results: DRs occurred in 28.4% of the 320 patients in the study. Patients with DRs had longer overall survival (7.7 [95% CI: 6.2–10.2]) vs 3.6 [3.2–4.1] months) and time to discontinuation (4.2 [3.0–4.9] vs 1.4 [1.0–1.5] months) than patients without DRs. Results were consistent in a validation analysis requiring three cycles of treatment. Conclusion: Liposomal irinotecan DRs were associated with improved clinical outcomes compared with patients without DRs.