Open AccessNext-generation sequencing of circulating tumor DNA for metastatic non-small cell lung cancer: a discussion on its implementation in the Brazilian clinical practice
Author(s) -
Luiz H. Araujo,
Carlos Gil Ferreira,
Clarissa Baldotto,
Clarissa Mathias,
Gilberto de Castro,
Renata A. Coudry
Publication year - 2021
Publication title -
future oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 72
eISSN - 1744-8301
pISSN - 1479-6694
DOI - 10.2217/fon-2020-0583
Subject(s) - medicine , circulating tumor dna , limiting , lung cancer , clinical practice , dna sequencing , cancer , oncology , circulating tumor cell , computational biology , medical physics , metastasis , dna , family medicine , biology , mechanical engineering , engineering , genetics
The objective of this review is to address the barriers limiting access to next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) for metastatic nonsquamous non-small cell lung cancer in Brazil and to propose its implementation in practice. A selected panel of lung cancer experts was provided with relevant prompts to address at a conference; a paper was then compiled on the topic. The authors propose specific and realistic recommendations for implementing access to ctDNA NGS. Further, the authors address all barriers and impediments mentioned within this review. There is a great need to increase ctDNA NGS for cancer care in Brazil. Adapting the current cancer testing framework is essential to expanding the use of this tool.