Open AccessConsensus paper: current state of first- and second-line therapy in advanced clear-cell renal cell carcinoma
Author(s) -
Peter J. Goebell,
Philipp Ivanyi,
Jens Bedke,
Lothar Bergmann,
Dominik Berthold,
Martin Boegemann,
Jonas Busch,
Christian Doehn,
Susanne Krege,
Margitta Retz,
Gunhild von Amsberg,
Marc-Oliver Grimm,
Viktor Gruenwald
Publication year - 2020
Publication title -
future oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 72
eISSN - 1744-8301
pISSN - 1479-6694
DOI - 10.2217/fon-2020-0403
Subject(s) - medicine , guideline , renal cell carcinoma , immunotherapy , intensive care medicine , oncology , targeted therapy , clinical practice , pathology , cancer , family medicine
The therapy of advanced (clear-cell) renal cell carcinoma (RCC) has recently experienced tremendous changes. Several new treatments have been developed, with PD-1 immune-checkpoint inhibition being the backbone of therapy. Diverse immunotherapy combinations change current first-line standards. These changes also require new approaches in subsequent lines of therapy. In an expert panel, we discussed the new treatment options and how they change clinical practice. While first-line immunotherapies introduce a new level of response rates, data on second-line therapies remains poor. This scenario poses a challenge for clinicians as guideline recommendations are based on historical patient cohorts and agents may lack the appropriate label for their in guidelines recommended use. Here, we summarize relevant clinical data and consider appropriate treatment strategies.