Open AccessAntifungal drugs work together to treat germs causing fungal infections
Author(s) -
Michael A. Pfaller,
Shawn A Messer,
Lalitagauri M. Deshpande,
Paul R. Rhomberg,
Eric Utt,
Mariana Castanheira
Publication year - 2021
Publication title -
future microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.797
H-Index - 82
eISSN - 1746-0921
pISSN - 1746-0913
DOI - 10.2217/fmb-2021-0086
Subject(s) - candida auris , voriconazole , anidulafungin , antifungal drugs , antifungal drug , drug , fluconazole , medicine , antifungal , pharmacology , dermatology , caspofungin
Life-threatening infections can be caused by a fungus called Candida auris (shortened to C. auris) that is found in the hospital environment. This study looked at how well different drugs could treat C. auris infection. Samples were collected from 36 people who had C. auris infection. The samples were treated with single drugs and in combination. We found that the main drug types did not work on most samples. Genetic differences we found in the C. auris samples could explain why the main drugs did not work. However, a drug called isavuconazole worked on almost all samples. We also found that a drug called anidulafungin worked better against C. auris when it was combined with either isavuconazole or another drug calledvoriconazole.