Open AccessNovel epigenetic link between gestational diabetes mellitus and macrosomia
Author(s) -
Brian T. Joyce,
Huikun Liu,
Leishen Wang,
Jun Wang,
Yinan Zheng,
Drew Nannini,
Alex Drong,
Stephanie Shiau,
Weiqin Li,
Junhong Leng,
Yun Shen,
Ru Gao,
Andrea A. Baccarelli,
Gang Hu,
Lifang Hou
Publication year - 2021
Publication title -
epigenomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.265
H-Index - 60
eISSN - 1750-1911
pISSN - 1750-192X
DOI - 10.2217/epi-2021-0096
Subject(s) - gestational diabetes , fetal macrosomia , diabetes mellitus , overweight , pregnancy , epigenetics , obstetrics , offspring , medicine , obesity , endocrinology , biology , gestation , genetics , gene
Background & objectives: Examine maternal gestational diabetes mellitus (GDM), macrosomia and DNA methylation in candidate genes IGF1 , IGF2 , H19 , ARHGRF11 , MEST , NR3C1 , ADIPOQ and RETN . Materials & methods: A total of 1145 children (572 GDM cases and 573 controls) from the Tianjin GDM study, including 177 with macrosomia, had blood DNA collection at median age 5.9 (range: 3.1-10.0). We used logistic regression to screen for associations with GDM and model macrosomia on 37 CpGs, and performed mediation analysis. Results: One CpG was associated with macrosomia at false discovery rate (FDR) <0.05 (cg14428359 in MEST ); two (cg19466922 in MEST and cg26263166 in IGF2 ) were associated at p < 0.05 but mediated 26 and 13%, respectively. Conclusion: MEST and IGF2 were previously identified for potential involvement in fetal growth and development (Trial Registration number: NCT01554358 [ClinicalTrials.gov]).