Open AccessGenome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study
Author(s) -
Ming Lu,
Xueying Qin,
Hexiang Peng,
Wenjing Gao,
Sara Hägg,
Weihua Cao,
Chunxiao Li,
Yu Chen,
Jun Lv,
Zengchang Pang,
Cong Liu,
Hua Wang,
Xuesong Wu,
Yunzhang Wang,
Liming Li
Publication year - 2021
Publication title -
epigenomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.265
H-Index - 60
eISSN - 1750-1911
pISSN - 1750-192X
DOI - 10.2217/epi-2021-0039
Subject(s) - biology , dna methylation , genetics , twin study , methylation , epigenetics , alcohol consumption , dna , gene , computational biology , alcohol , gene expression , heritability , biochemistry
Aim: Alcohol intake alters DNA methylation profiles and methylation might mediate the association between alcohol and disease, but limited number of positive CpG sites repeatedly replicated. Materials & methods: In total, 57 monozygotic (MZ) twin pairs discordant for alcohol drinking from the Chinese National Twin Registry and 158 MZ and dizygotic twin pairs in the Swedish Adoption/Twin Study of Aging were evaluated. DNA methylation was detected using the Infinium HumanMethylation450 BeadChip. Results: Among candidate CpG sites, cg07326074 was significantly correlated with drinking after adjusting for covariates in MZ twins in both datasets but not in the entire sample or dizygotic twins. Conclusion: The hypermethylation of cg07326074, located in the tumor-promoting gene C16orf59 , was associated with alcohol consumption.