Open AccessMaternal lipodome across pregnancy is associated with the neonatal DNA methylome
Author(s) -
Jennifer L LaBarre,
Carolyn McCabe,
Tamara R. Jones,
Peter Song,
Steven E. Domino,
Marjorie C. Treadwell,
Dana C. Dolinoy,
Charles F. Burant,
Jaclyn M. Goodrich
Publication year - 2020
Publication title -
epigenomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.265
H-Index - 60
eISSN - 1750-1911
pISSN - 1750-192X
DOI - 10.2217/epi-2020-0234
Subject(s) - lipidome , dna methylation , biology , epigenomics , epigenome , lipidomics , differentially methylated regions , cord blood , metabolome , pregnancy , genetics , methylation , bioinformatics , dna , gene , gene expression , metabolomics
Aim: To classify the association between the maternal lipidome and DNA methylation in cord blood leukocytes. Materials & methods: Untargeted lipidomics was performed on first trimester maternal plasma (M1) and delivery maternal plasma (M3) in 100 mothers from the Michigan Mother-Infant Pairs cohort. Cord blood leukocyte DNA methylation was profiled using the Infinium EPIC bead array and empirical Bayes modeling identified differential DNA methylation related to maternal lipid groups. Results: M3-saturated lysophosphatidylcholine was associated with 45 differentially methylated loci and M3-saturated lysophosphatidylethanolamine was associated with 18 differentially methylated loci. Biological pathways enriched among differentially methylated loci by M3 saturated lysophosphatidylcholines were related to cell proliferation and growth. Conclusion: The maternal lipidome may be influential in establishing the infant epigenome.