Methylome-Wide Association Study of Central Adiposity Implicates Genes Involved in Immune and Endocrine Systems | Zendy

Anne E. Justice | Zendy; Geetha Chittoor | Zendy; Rahul Gondalia | Zendy; Phillip E. Melton | Zendy; Elise Lim | Zendy; Megan L. Grove | Zendy; Eric A. Whitsel | Zendy; Yongmei Liu | Zendy; L. Adrienne Cupples | Zendy; Lindsay FernándezRhodes | Zendy; Weihua Guan | Zendy; Jan Bressler | Zendy; Myriam Fornage | Zendy; Eric Boerwinkle | Zendy; Yun Li | Zendy; Ellen W. Demerath | Zendy; Nancy L. HeardCosta | Zendy; Daniel Levy | Zendy; James D. Stewart | Zendy; Andrea Baccarelli | Zendy; Lifang Hou | Zendy; Karen N. Conneely | Zendy; Trevor A. Mori | Zendy; Lawrence J. Beilin | Zendy; RaeChi Huang | Zendy; Penny GordonLarsen | Zendy; Annie Green Howard | Zendy; Kari E. North | Zendy

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Methylome-Wide Association Study of Central Adiposity Implicates Genes Involved in Immune and Endocrine Systems

Author(s) -

Anne E. Justice,

Geetha Chittoor,

Rahul Gondalia,

Phillip E. Melton,

Elise Lim,

Megan L. Grove,

Eric A. Whitsel,

Yongmei Liu,

L. Adrienne Cupples,

Lindsay FernándezRhodes,

Weihua Guan,

Jan Bressler,

Myriam Fornage,

Eric Boerwinkle,

Yun Li,

Ellen W. Demerath,

Nancy L. HeardCosta,

Daniel Levy,

James D. Stewart,

Andrea Baccarelli,

Lifang Hou,

Karen N. Conneely,

Trevor A. Mori,

Lawrence J. Beilin,

RaeChi Huang,

Penny GordonLarsen,

Annie Green Howard,

Kari E. North

Publication year - 2020

Publication title -

epigenomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.265

H-Index - 60

eISSN - 1750-1911

pISSN - 1750-192X

DOI - 10.2217/epi-2019-0276

Subject(s) - waist , dna methylation , framingham heart study , cpg site , body mass index , biology , obesity , waist–hip ratio , epigenetics , genome wide association study , medicine , endocrinology , physiology , framingham risk score , genetics , single nucleotide polymorphism , gene , genotype , gene expression , disease

Aim: We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. Materials & methods: We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP , ADCY7 , SREBF1 and RAP1GAP2 that had not previously been associated with obesity-related traits.

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