Open AccessMethylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems
Author(s) -
Anne E. Justice,
Geetha Chittoor,
Rahul Gondalia,
Phillip E. Melton,
Elise Lim,
Megan L. Grove,
Eric A. Whitsel,
ChingTi Liu,
L. Adrienne Cupples,
Lindsay Fernández-Rhodes,
Weihua Guan,
Jan Bressler,
Myriam Fornage,
Eric Boerwinkle,
Yun Li,
Ellen W. Demerath,
Nancy L. HeardCosta,
Daniel Levy,
James D. Stewart,
Andrea A. Baccarelli,
Lifang Hou,
Karen N. Conneely,
Trevor A. Mori,
Lawrence J. Beilin,
Rae Chi Huang,
Penny GordonLarsen,
Annie Green Howard,
Kari E. North
Publication year - 2020
Publication title -
epigenomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.265
H-Index - 60
eISSN - 1750-1911
pISSN - 1750-192X
DOI - 10.2217/epi-2019-0276
Subject(s) - biology , endocrine system , dna methylation , immune system , gene , genetics , association (psychology) , bioinformatics , computational biology , endocrinology , gene expression , hormone , philosophy , epistemology
Aim: We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. Materials & methods: We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). Results & conclusion: We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near TXNIP , ADCY7 , SREBF1 and RAP1GAP2 that had not previously been associated with obesity-related traits.