Open AccessSex-specific DNA methylation differences in people exposed to polybrominated biphenyl
Author(s) -
Sarah W. Curtis,
Sabrina A. Gerkowicz,
Dawayland O. Cobb,
Varun Kilaru,
Metrecia L. Terrell,
M. Elizabeth Marder,
Dana Boyd Barr,
Carmen J. Marsit,
Michele Marcus,
Karen N. Conneely,
Alicia K. Smith
Publication year - 2020
Publication title -
epigenomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.265
H-Index - 60
eISSN - 1750-1911
pISSN - 1750-192X
DOI - 10.2217/epi-2019-0179
Subject(s) - epigenome , polybrominated biphenyls , dna methylation , biology , physiology , environmental health , polybrominated diphenyl ethers , toxicology , genetics , medicine , pollutant , ecology , gene , gene expression
Aim: Michigan residents were exposed to polybrominated biphenyls (PBBs) when it was accidentally added to the food supply. Highly exposed individuals report sex-specific health problems, but the underlying biological mechanism behind these different health risks is not known. Materials and methods: DNA methylation in blood from 381 women and 277 men with PBB exposure was analyzed with the MethylationEPIC BeadChip. Results: 675 CpGs were associated with PBBs levels in males, while only 17 CpGs were associated in females (false discovery rate <0.05). No CpGs were associated in both sexes. These CpGs were enriched in different functional regions and transcription factor binding sites in each sex. Conclusion: Exposure to PBBs may have sex-specific effects on the epigenome that may underlie sex-specific adverse health outcomes.