Open AccessThe impact of mismatch repair status to the preoperative staging of colon cancer: implications for clinical management
Author(s) -
Emilie Erbs,
Søren Rafael Rafaelsen,
Jan Lindebjerg,
Lars Henrik Jensen,
Torben Frøstrup Hansen
Publication year - 2020
Publication title -
colorectal cancer
Language(s) - English
Resource type - Journals
eISSN - 1758-1958
pISSN - 1758-194X
DOI - 10.2217/crc-2020-0001
Subject(s) - medicine , colorectal cancer , pathological , dna mismatch repair , oncology , lymph node , cancer , stage (stratigraphy) , immunohistochemistry , correlation , paleontology , geometry , mathematics , biology
Aims: We sought to investigate if mismatch repair (MMR) status influences the preoperative staging of local colon cancer. Methods: Data from 590 patients in the Danish Colorectal Cancer Group national clinical database who were operated on for stage I-III colon cancer in 2010-15 were included. MMR status was determined by immunohistochemistry. Results: 22.9% had deficient(d) MMR tumors. Correlation of the clinical and pathological T-category was significant for both groups. The correlation of pre- and postoperative N-category was inferior (p >0.05) in dMMR cancers compared to a significant (p <0.01) correlation in proficient MMR cancers. 64.8% of dMMR tumors assessed node-positive demonstrated no sign of metastatic involvement at the postoperative assessment. Conclusion: MMR status seems to impact the accuracy of preoperative lymph node staging.