Open AccessIdentification of miRNAs correlating with stage and progression of colorectal cancer
Author(s) -
Milad Asadi,
Shoan Taheri Talesh,
Morten F. Gjerstorff,
Dariush Shanehbandi,
Behzad Baradaran,
Shahryar Hashemzadeh,
Venus Zafari
Publication year - 2019
Publication title -
colorectal cancer
Language(s) - English
Resource type - Journals
eISSN - 1758-1958
pISSN - 1758-194X
DOI - 10.2217/crc-2018-0014
Subject(s) - microrna , colorectal cancer , medicine , carcinogenesis , cancer , disease , oncology , stage (stratigraphy) , pathogenesis , downregulation and upregulation , bioinformatics , etiology , cancer research , gene , biology , genetics , paleontology
Aim: miRNAs control biological processes that are implicated in carcinogenesis, and have been researched as potential biomarkers for colorectal cancer (CRC). The aim of the current study was to evaluate the miRNA expression profile in CRC patients to determine their potential to be used as biomarkers in the disease. Materials & methods: Total 47 tissues and their matched marginal tissues, as control group, were obtained from CRC patients. The transcript levels of a selected panel of 15 cancer-associated miRNAs were quantified via real-time gene expression method. Results: miR-155, miR130a, miR-181b, miR-196a, miR-200c and miR-224 were significantly upregulated, while miR122, miR-132, miR-203b, miR330, miR-323, miR-378a-3p and miR-598 we significantly downregulated in CRC. Conclusion: We identified a panel of miRNAs that may be involved in the etiology and pathogenesis of CRC, and may be used for novel diagnostic and therapeutic strategies.