Open AccessSmall cell glioblastoma multiforme: a case series and clinicopathological update
Author(s) -
Arun Kumar Yadav,
Renu Madan,
Debajyoti Chatterjee,
Shalin Dhiman,
Shikha Goyal,
Narendra Kumar,
Sushanta K. Sahoo
Publication year - 2020
Publication title -
cns oncology
Language(s) - English
Resource type - Journals
eISSN - 2045-0915
pISSN - 2045-0907
DOI - 10.2217/cns-2020-0016
Subject(s) - temozolomide , glioblastoma , medicine , pathological , radiation therapy , adjuvant , oncology , adjuvant radiotherapy , pathology , cancer research
Small cell glioblastoma (scGBM) is a rare histological variant of classical glioblastoma (GBM). Presence of necrosis and microvascular proliferation is not essential for the diagnosis. It is thought to have more aggressive behavior as compared with classical GBM; however, because of its rarity standard treatment guidelines are not available. Adjuvant treatment for these cancers consists of postoperative radiotherapy with concurrent and maintenance temozolomide similar to classical GBM. Here we present a case series of five small cell glioblastoma patients along with the clinical-pathological review.