Open AccessUsing real-world evidence in healthcare from Western to Central and Eastern Europe: a review of existing barriers
Author(s) -
Maria Kamusheva,
Bertalan Németh,
Antal Zemplényi,
Zoltán Kaló,
Jamie Elvidge,
Maria Dimitrova,
Johan Pontén,
Konstantin Tachkov,
Zornitsa Mitkova
Publication year - 2022
Publication title -
journal of comparative effectiveness research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.567
H-Index - 23
eISSN - 2042-6313
pISSN - 2042-6305
DOI - 10.2217/cer-2022-0065
Subject(s) - harmonization , standardization , medicine , transferability , real world evidence , health care , health technology , engineering management , economic growth , engineering , political science , law , physics , acoustics , economics , human capital
As part of the HTx (Next Generation Health Technology Assessment) project, this study was aimed at identifying the main barriers for application of real-world evidence (RWE) for the purposes of health technology assessment in the Central and Eastern European countries. A mixed methods approach was employed to identify the main barriers: a scoping review of the literature and a series of discussions with stakeholders. Based on the applied approaches, we attempted to summarize the main barriers and challenges related to transferability of RWE in five main groups: technical, regulatory, clinical, scientific and perceptional barriers. Further research should pursue the development of detailed, consensus-based guidelines to improve the harmonization and standardization of RWE.