Open AccessHealthcare utilization and guideline-directed medical therapy in heart failure patients with reduced ejection fraction
Author(s) -
Peter A. McCullough,
Hirsch Mehta,
Colin Barker,
Joanna Van Houten,
Sarah Mollenkopf,
Candace Gunnarsson,
Michael P. Ryan,
David P. Cork
Publication year - 2021
Publication title -
journal of comparative effectiveness research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.567
H-Index - 23
eISSN - 2042-6313
pISSN - 2042-6305
DOI - 10.2217/cer-2021-0118
Subject(s) - medicine , ejection fraction , guideline , medical therapy , heart failure , angiotensin receptor blockers , population , ace inhibitor , emergency medicine , cardiology , angiotensin converting enzyme , blood pressure , pathology , environmental health
Aim: This study examines the effect of guideline-directed medical therapy (GDMT) on healthcare utilization in patients with heart failure with reduced ejection fraction from Optum ® Integrated File from 1 January 2007 to 30 June 2020. Materials & methods: Patients with both a beta blocker and either an ACE inhibitor (ACE-I), angiotensin receptor blocker (ARB) or angiotensin receptor neprilysin inhibitor were assigned to the GDMT cohort. All others were not on GDMT. Results: Estimated annual all cause hospitalizations and emergency department visits per 100 patients was 29% (80 vs 62 patients) and 26% higher (54 vs 43 patients; p < 0.0001) and annualized hospital days were longer (1.88 vs 1.64; p = 0.0020) for patients not on GDMT. Conclusion: In a real-world population, heart failure with reduced ejection fraction, patients not optimally managed on GDMT had higher annualized healthcare utilization when compared with patients on GDMT.