Open AccessPrognostic and predictive value of microsatellite instability status among patients with colorectal cancer
Author(s) -
Firas Baidoun,
Anas M. Saad,
Omar AbdelRahman
Publication year - 2021
Publication title -
journal of comparative effectiveness research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.567
H-Index - 23
eISSN - 2042-6313
pISSN - 2042-6305
DOI - 10.2217/cer-2021-0013
Subject(s) - medicine , microsatellite instability , colorectal cancer , chemotherapy , oncology , stage (stratigraphy) , proportional hazards model , predictive value , multivariate analysis , cancer , adenocarcinoma , microsatellite , paleontology , biochemistry , allele , chemistry , biology , gene
Objectives: Compare overall survival (OS) between microsatellite instability (MSI) high and MSI-stable and analyze the effect of chemotherapy on OS. Methods: National cancer database was queried for patients diagnosed with colorectal adenocarcinoma between 2010 and 2016. We evaluated the OS and the chemotherapy effect using Kaplan–Meier estimates and multivariate Cox regression analyses. Results: Total of 30,436 stage II patients and 30,302 stage III patients were included. In stage II with high-risk features and MSI-high, patients who received chemotherapy had better OS compared to patients who didn't receive chemotherapy. The same was found in stage II with no high-risk features and MSI-high group. Conclusion: Stage II colorectal cancer patients with high-risk features and MSI-high who received chemotherapy have better OS compared to patients who didn't receive chemotherapy.