Open AccessA qualitative evaluation of patient and healthcare provider knowledge, attitudes, and behavior for safety and use of pexidartinib
Author(s) -
Maribel Salas,
Michele Julian,
Leonidas Drogaris,
Zahidul Islam,
Mackenzie Henderson,
Annette Stemhagen,
Natalie O’Donnell,
Nora Tu
Publication year - 2021
Publication title -
journal of comparative effectiveness research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.567
H-Index - 23
eISSN - 2042-6313
pISSN - 2042-6305
DOI - 10.2217/cer-2020-0147
Subject(s) - medicine , terminology , comprehension , telephone survey , health care , health professionals , inclusion (mineral) , qualitative research , family medicine , qualitative property , medline , social psychology , psychology , philosophy , linguistics , social science , marketing , machine learning , sociology , computer science , economics , political science , law , business , economic growth
Aim: Pexidartinib is approved in the USA for the treatment of symptomatic tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to improvement with surgery. Due to risk of serious liver injury, a survey of patient and healthcare provider (HCP) knowledge, attitudes, and behavior (KAB) of the risks was required. Materials & methods: Prior to KAB survey execution, structured telephone interviews with 12 patients and 12 HCPs were conducted. Results: The interviews revealed that patients had difficulty with the complexity and wordiness of some of the questions, while HCPs noted that some questions were repetitive with terminology that was not self-explanatory. Of the 15 questions initially in the patient survey, nine were modified for survey inclusion. For the HCP survey, 10 of 18 questions were modified. Conclusion: Qualitative research prior to KAB surveys is recommended to improve comprehension and data quality.