Open AccessSystematic review of societal costs associated with stroke, bleeding and monitoring in atrial fibrillation
Author(s) -
Amber Martin,
Alessandra Garcia Reeves,
Samantha Berger,
Manuela Di Fusco,
Gail Wygant,
Mirko Savone,
Kassandra R. Snook,
Miejati,
Tereza Lanitis
Publication year - 2019
Publication title -
journal of comparative effectiveness research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.567
H-Index - 23
eISSN - 2042-6313
pISSN - 2042-6305
DOI - 10.2217/cer-2019-0089
Subject(s) - medicine , atrial fibrillation , stroke (engine) , major bleeding , medline , intensive care medicine , emergency medicine , mechanical engineering , political science , law , engineering
Aim: Economic consequences associated with the rise in nonvitamin K antagonist oral anticoagulant use on a societal level remain unclear. Materials & methods: Evidence from the past decade on the societal economic burden associated with stroke, bleeding and international normalized ratio monitoring in atrial fibrillation was collected and summarized through a systematic literature review. Results: There were 14 studies identified that reported indirect costs, which were highest among patients with hemorrhagic stroke and intracranial hemorrhage. The contribution of indirect costs to the total was marginal during acute treatment but substantially increased (30–50%) 2 years after stroke and bleeding events. Conclusion: Limited data were available on societal costs in atrial fibrillation and further research is warranted.