Gene Expression Profiling of Triple-Negative Breast Tumors with Different Expression of Secreted Protein Acidic And Cysteine Rich (SPARC) | Zendy

Paulo R. de Alcantara Filho | Zendy; Flávia Rotea Mangone | Zendy; Ana Carolina Pavanelli | Zendy; Simone Aparecida de Bessa Garcia | Zendy; Suely ogaki | Zendy; Cynthia AB de Toledo Osório | Zendy; Victor P. Andrade | Zendy; María Aparecida Nagai | Zendy

Open Access

Gene Expression Profiling of Triple-Negative Breast Tumors with Different Expression of Secreted Protein Acidic And Cysteine Rich (SPARC)

Author(s) -

Paulo R. de Alcantara Filho,

Flávia Rotea Mangone,

Ana Carolina Pavanelli,

Simone Aparecida de Bessa Garcia,

Suely ogaki,

Cynthia AB de Toledo Osório,

Victor P. Andrade,

María Aparecida Nagai

Publication year - 2018

Publication title -

breast cancer management

Language(s) - English

Resource type - Journals

eISSN - 1758-1931

pISSN - 1758-1923

DOI - 10.2217/bmt-2017-0019

Subject(s) - tissue microarray , triple negative breast cancer , breast cancer , gene expression profiling , immunohistochemistry , medicine , microarray , transcriptome , gene expression , microarray analysis techniques , cancer research , complementary dna , protein expression , cysteine , proteomics , pathology , bioinformatics , gene , biology , cancer , genetics , biochemistry , enzyme

Aim: To determine the expression signature of triple-negative breast cancer (TNBC) with differences of secreted protein acidic and rich in cysteine expression and clinical behavior. Patients, materials & methods: cDNA microarray analysis was performed to determine the expression profiling of TNBC, characterized regarding secreted protein acidic and rich in cysteine expression status. Immunohistochemistry analysis on tissue microarrays containing an independent cohort of TNBC was performed for validation. Results: Negative staining of SOHLH2 and positive staining of DNAJC12 and LIM1 was correlated with a poor outcome of the patients. Conclusion: Our findings provide new information on transcriptome changes associated with the clinical behavior of TNBC that may serve as a potential tool for the identification and characterization of new candidate biomarkers.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research