Open AccessDiagnostic value of serum tumor-associated autoantibodies in esophageal cancer
Author(s) -
Kangjia Xiao,
Xiaolu Ma,
Yanchun Wang,
Cheng Zhu,
Lin Guo,
Renquan Lu
Publication year - 2021
Publication title -
biomarkers in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 44
eISSN - 1752-0371
pISSN - 1752-0363
DOI - 10.2217/bmm-2021-0351
Subject(s) - medicine , receiver operating characteristic , nomogram , esophageal cancer , autoantibody , area under the curve , gastroenterology , cancer , oncology , immunology , antibody
Aim: To explore the application value of serum autoantibodies in the early diagnosis of esophageal cancer. Materials & methods: A total of 130 patients with esophageal cancer and 110 controls were included and tested by ELISA. Results: According to the receiver operating characteristic curve, total sensitivity is 83.08%, total specificity is 72.73%. A nomogram was established based on the positive judgment standard, the area under the receiver operating characteristic curve was calculated to be 0.880 after verification with the calibration curve. A 2-week follow-up analysis found compared with the preoperative control, the postoperative model integral value will significantly decrease. Conclusion: The combination of serum autoantibody groups has certain clinical application value in the early diagnosis of esophageal cancer and can be used as an auxiliary index for early diagnosis.