Open AccessEstablishment of reference intervals of ten commonly used clinical chemistry analytes: a real-world study in China
Author(s) -
Sailimai Man,
Yongxiang Gao,
Jun Lv,
Cheng Jin,
Weiru Pan,
Hong Zhao Jiaping Wei,
Bo Wang,
Liming Li,
Yi Ning
Publication year - 2021
Publication title -
biomarkers in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 44
eISSN - 1752-0371
pISSN - 1752-0363
DOI - 10.2217/bmm-2021-0233
Subject(s) - medicine , guideline , blood urea nitrogen , creatine kinase , creatinine , alkaline phosphatase , population , roche diagnostics , urea , reference values , triglyceride , cholesterol , endocrinology , biochemistry , pathology , chemistry , environmental health , enzyme
Aim: This real-world study was aimed at establishing reference intervals (RIs) of ten commonly used clinical chemistry analytes (total cholesterol, triglycerides, Apo A1, Apo B, creatine kinase (CK), CK isoenzyme MB, glucose, alkaline phosphatase, γ-glutamyltransferase and blood urea nitrogen) in an apparently healthy population in China. Materials & methods: A total of 17,356 healthy participants aged 18–79 years who underwent check-up at MJ Health Check-up Center were included. The establishment of RIs was performed according to the Clinical and Laboratory Standards Institute EP28-A3c guideline. Roche Cobas c701 automatic analyzer (Roche Diagnostics, Mannheim, Germany) was employed to measure the concentrations of analytes. Results: Total cholesterol, triglycerides, Apo B, CK, alkaline phosphatase, glucose, γ-glutamyltransferase and blood urea nitrogen required gender and age-specific partitioning. Conclusion: The RIs established in this study were parallel to current national standards and previous RIs established in Chinese population. Real-world studies may play an important and practical role in the determination of RIs in the future.