Open AccessExtracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful?
Author(s) -
Andrew Dhawan
Publication year - 2021
Publication title -
biomarkers in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 44
eISSN - 1752-0371
pISSN - 1752-0363
DOI - 10.2217/bmm-2021-0092
Subject(s) - medicine , cerebrospinal fluid , disease , extracellular , microrna , bioinformatics , biomarker , oncology , pathology , gene , biology , genetics
Aim: The aim of our work is to aggregate data from publications of cerebrospinal fluid extracellular miRNA to identify candidate diagnostic biomarkers, and those warranting further study. Materials & methods: Data were pooled from nine studies, encompassing 864 patients across 16 diseases. Unsupervised clustering grouped patients by a broad category of diseases. Results & conclusion: Compared with healthy controls, in patients with Alzheimer’s disease, hsa-miR-767-5p was overexpressed (p < 0.001) and in patients with Huntington’s disease, hsa-miR-361-3p was underexpressed (p < 10 -4 ). We also define a subset of extracellular miRNA as candidate biomarkers that are robustly detected across patients, studies and diseases; thereby, warranting further study.