Open AccessPrevention of cardiac surgery-associated acute kidney injury by risk stratification using (TIMP-2)*(IGFBP7)
Author(s) -
Cyril Couturier,
Nicolas Maillard,
Christophe Mariat,
J. Morel,
Jean-Charles Palao,
Jean-Baptiste Bouchet,
Guillaume Claisse
Publication year - 2021
Publication title -
biomarkers in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 44
eISSN - 1752-0371
pISSN - 1752-0363
DOI - 10.2217/bmm-2020-0656
Subject(s) - medicine , cohort , acute kidney injury , urinary system , incidence (geometry) , retrospective cohort study , cohort study , intensive care medicine , optics , physics
Aim: The purpose of this study was to assess urinary (TIMP-2)*(IGFBP7) for prevention of acute kidney injury (AKI) in patients undergoing elective cardiac surgery. Materials & methods: Two retrospective cohorts were analyzed before and after the implementation of urinary (TIMP-2)*(IGFBP7). The control cohort had a standard supportive care. For the (TIMP-2)*(IGFBP7) cohort, patients with the (TIMP-2)*(IGFBP7) >0.3 received renal supportive measures. Results: A total of 382 patients were included, 197 in the control cohort and 185 in intervention cohort. The incidence of AKI was significantly reduced in the (TIMP-2)*(IGFBP7) cohort (20.5 vs 29.9%, p < 0.05). In multivariate analysis, patients of the (TIMP-2)*(IGFBP7) cohort had a lower risk of developing AKI (p = 0.029). Conclusion: In conclusion, renal supporting care based on AKI risk stratification using urinary (TIMP-2)*(IGFBP7) may reduce AKI incidence.