Open AccessPredictive value of circulating sex hormone-binding globulin for gestational diabetes: a meta-analysis
Author(s) -
Xi Luo,
Weixiong Cai,
Junxian Song,
Cuicui Duan,
Wei Wu,
Yu-Jing Man,
Xiaoke Wu,
Jian Xu
Publication year - 2021
Publication title -
biomarkers in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 44
eISSN - 1752-0371
pISSN - 1752-0363
DOI - 10.2217/bmm-2020-0487
Subject(s) - medicine , sex hormone binding globulin , gestational diabetes , odds ratio , diagnostic odds ratio , likelihood ratios in diagnostic testing , meta analysis , cochrane library , receiver operating characteristic , obstetrics , diabetes mellitus , confidence interval , pregnancy , gestation , hormone , endocrinology , biology , androgen , genetics
Aim: To detect predictive value of preconception or early pregnancy sex hormone-binding globulin (SHBG) for subsequent gestational diabetes mellitus (GDM). Materials & methods: We searched Embase, Medline, PubMed, Web of Science and Cochrane library up to January 2020. Studies assessing diagnostic performance of SHBG for GDM diagnosed by well-defined diagnostic criteria using oral glucose tolerance test. Results: Totally seven studies with 1947 women were included and 247 were diagnosed as GDM. SHBG had a combined diagnostic odds ratio of 6.68 (95% CI: 4.58–9.74), sensitivity of 0.70 (95% CI: 0.51–0.84), specificity of 0.74 (95% CI: 0.52–0.88), positive likelihood ratio of 2.49 (95% CI: 1.73–3.57) and negative likelihood ratio of 0.37 (95% CI: 0.23–0.61). The area under the summary receiver operating characteristic curve was 0.78 (95% CI: 0.74–0.82). Conclusion: SHBG had a predictive value for GDM and might improve GDM screening. However, heterogeneity between studies warrants more research into this topic.