Open AccessExosomes as possible spread factor and potential biomarkers in Alzheimer's disease: current concepts
Author(s) -
Ryszard Pluta,
Marzena Ułamek-Kozioł,
Sławomir Januszewski,
Stanisław J. Czuczwar
Publication year - 2018
Publication title -
biomarkers in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 44
eISSN - 1752-0371
pISSN - 1752-0363
DOI - 10.2217/bmm-2018-0034
Subject(s) - microvesicles , disease , extracellular vesicles , medicine , exosome , alzheimer's disease , extracellular , amyloid (mycology) , phenotype , neuroscience , microbiology and biotechnology , microrna , biology , pathology , biochemistry , gene
Increasing evidence points that important factors during development/spread of Alzheimer's disease in brain tissue are small extracellular vesicles, called exosomes. Exosomes comprise disease-related biomolecules such as the amyloid protein precursor, β-amyloid peptide and tau protein. Exosomes are hypothesized to facilitate the spread of β-amyloid peptide and tau protein from their cells of origin (e.g., neurons) to the extracellular space and to recipient cells to alter their phenotype and function. The roles of exosomes carry a rich biomolecules cargo in physiology and pathology is poorly understood. In this review, we will consider new information about the role of exosomes in Alzheimer's disease spreading and progression and underline their possible usefulness as the future diagnostic antemortem biomarkers in this devastating disorder.